氧化石墨烯於類鐸受體/自體吞噬及抗癌之應用METHOD OF INDUCING AUTOPHAGY AND ACTIVATING TOLL-LIKE RECEPTOR

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/622,457

專利證號

US 9,421,224 B2

專利獲證名稱

氧化石墨烯於類鐸受體/自體吞噬及抗癌之應用METHOD OF INDUCING AUTOPHAGY AND ACTIVATING TOLL-LIKE RECEPTOR

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2016/08/23

技術說明

本發明的目的是提供一種新的機制，通過它的細胞響應的納米材料之安全性評價的重要性。 [在細胞中誘導自噬的方法是通過以有效量來誘導自噬的細胞，其中所述細胞表達的TLR-4中的至少一個與石墨烯氧化物（GO）的細胞接觸而實現（Toll樣受體4）和TLR-9（Toll樣受體9）。 根據另一個實施例中，激活Toll樣受體在細胞中的方法是通過用氧化石墨烯的細胞接觸有效量的可激活TLR-2的至少一種來實現（Toll樣受體2） ，TLR-4（Toll樣受體4），TLR-7（Toll樣受體7）和TLR-9（Toll樣受體9）中的細胞，從而TLR-2，TLR-4中的至少一個， TLR-7和TLR-9將在細胞激活。 The present invention is directed to provide a new mechanism by which cells respond to nanomaterials and underscores the importance of future safety evaluation of nanomaterials. According to an embodiment, A method of inducing autophagy in a cell is achieved by contacting the cell with graphene oxide (GO) in an amount effective to induce autophagy in the cell, wherein the cell expresses at least one of TLR-4 (Toll-like receptor 4) and TLR-9 (Toll-like receptor 9). According to another embodiment, a method of activating a Toll-like receptor in a cell is achieved by contacting the cell with graphene oxide in an amount effective to activate a at least one of TLR-2 (Toll-like receptor 2), TLR-4 (Toll-like receptor 4), TLR-7 (Toll-like receptor 7) and TLR-9 (Toll-like receptor 9) in the cell, whereby at least one of TLR-2, TLR-4, TLR-7 and TLR-9 are activated in the cell.

備註

連絡單位 (專責單位/部門名稱)

智財技轉組

連絡電話

03-5715131-62219

網址