AUTOMATIC MICROFLUIDIC SYSTEM FOR ANTIBIOTIC SUSCEPTIBILITY TESTING AND METHOD OF OPERATING THEREOF

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

15/582,781

專利證號

US 10,610,863

專利獲證名稱

AUTOMATIC MICROFLUIDIC SYSTEM FOR ANTIBIOTIC SUSCEPTIBILITY TESTING AND METHOD OF OPERATING THEREOF

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2020/04/07

技術說明

本發明提供一種用於自動化進行抗生素感受性試驗之微流體晶片系統，其包含一微流體晶片，且前述晶片至少包含流體儲存單元、反應單元、氣動式微幫浦單元與複數個閥門單元。藉此，本發明之微流體晶片系統可自動化進行抗生素感受性試驗中如菌液分配及抗生素濃度稀釋等需人工的動作，並可精確有效地進行流體的定量運輸與混合，以快速且準確地偵測出最小抑菌濃度或微量抑制濃度指數。此外，本發明之微流體晶片系統所進行的抗生素感受性試驗較傳統方法快速，且可不需要傳統檢驗上的專業人工判讀或昂貴儀器即可獲得檢驗結果，應可達到快速篩檢，減少醫院人力成本之效果。 An automatic microfluidic system for antibiotic susceptibility testing of the present disclosure at least includes a microfluidic chip. The microfluidic chip at least includes a fluid storage unit, a reaction unit, a pneumatic micro-pumping unit and a plurality of valve units. Accordingly, the developed microfluidic system provides a simple method for performing an arrangement of the bacterial solution and a dilution of the antibiotic solution during the antibiotic susceptibility testing in an automated format. The present microfluidic system can transfer fluids quantitatively and then mix the fluids efficiently. Therefore, a minimum inhibitory concentration or a fractional inhibitory concentration index can be rapidly and preciously detected through the present disclosure.

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連絡單位 (專責單位/部門名稱)

智財技轉組

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03-5715131-62219

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