Genetic variants associated with lithium response in bipolar disorder

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/764,448

專利證號

US 9,797,015 B2

專利獲證名稱

Genetic variants associated with lithium response in bipolar disorder

專利所屬機關 (申請機關)

中央研究院

獲證日期

2017/10/24

技術說明

本發明提供一種檢測鋰鹽對雙極性情感疾病(Biopolar disorder)患者的療效之方法，該方法包含從雙極性情感疾病患者取得一樣本，且分析該樣本存在或不存在一個或多個谷氨酸脱羧酶樣 1 (glutamate decarboxylase-like 1，GADL1)基因變異，其中該基因變異係選自於︰SNP rs17026688對偶基因型為T、SNP rs17026651對偶基因型為G及GADL1 IVS8+48delG。一個或多個的GADL1基因變異存在表示該患者對鋰鹽治療具有療效。 Described herein is a method of determining lithium responsiveness in a bipolar disorder patient. The method includes obtaining a sample from a patient having bipolar disorder, and assaying the sample for the presence or absence of one or more glutamate decarboxylase-like 1 (GADL1) gene variants selected from the group consisting of a T allele of the single nucleotide polymorphism (SNP) rs17026688, a G allele of the SNP rs17026651, and GADL1 IVS8+48delG. The presence of one or more of the GADL1 gene variants indicates that the patient is responsive to lithium treatment.

備註

本部(收文號1100056059)同意該校110年9月3日智財字第1100507762號函申請終止維護專利(中研院)

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02-2787-2508

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