CELL SHEET CONSTRUCT FOR NEUROVASCULAR RECONSTRUCTION AND MANUFACTURE THEREOF

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

16/705,314

專利證號

US 11,439,730 B2

專利獲證名稱

CELL SHEET CONSTRUCT FOR NEUROVASCULAR RECONSTRUCTION AND MANUFACTURE THEREOF

專利所屬機關 (申請機關)

國防醫學院

獲證日期

2022/09/13

技術說明

本研究團隊首創將人類腦神經幹細胞及腦微血管內皮細胞共同培養，製成可分化出神經元及血管分枝之細胞層片，用以重建大腦等神經血管組織。臨床前療效驗證採用大鼠腦創傷模式，進行神經幹細胞層片移植治療，影像學及神經行為等評估，顯示治療組大鼠之神經功能復原較佳，將擴展應用於腦中風、糖尿病足、退化性腦病變等領域。 We first construct the cell sheet composed of human neural stem cells, endothelial cells and extracellular matrix, which are committed to generating neurovascular networks. Such novel building blocks have been applied to surgical brain trauma and spinal nerve injuries. Improvements in neurological assessments and histological evidence of regenerating functional neurovascular tissue have been demonstrated in animal models. We are applying these novel techniques to spinal cord injury and stroke.

備註

連絡單位 (專責單位/部門名稱)

研究發展室

連絡電話

(02)8792-3100分機18079

網址