RECOMBINANT RSV ANTIGENS, NUCLEIC ACID MOLECULES ENCODING THE ANTIGENS, AND VACCINE COMPOSITIONS COMPRISING THE SAME

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

16/462,757

專利證號

US 11,464,850 B2

專利獲證名稱

RECOMBINANT RSV ANTIGENS, NUCLEIC ACID MOLECULES ENCODING THE ANTIGENS, AND VACCINE COMPOSITIONS COMPRISING THE SAME

專利所屬機關 (申請機關)

國立臺灣大學

獲證日期

2022/10/11

技術說明

為了更加了解RSV疫苗免疫後的抗RSV F-相關的抗體反應，我們構建了利用在HRN和HRC之間插入RSV抗原決定組II（A1）,IV（A2）及Ø的重組蛋白HRØ24來模仿RSV F蛋白的天然三聚體構象,並在小鼠中進行了針對HRØ24，FIRSV，抗原決定組Ø，II和IV的體液免疫反應以及保護效力的評估。利用這種方法，我們證明了HRØ24所引起免疫反應的特性和保護的機制。 To get a better understanding of the RSV F-associated antibody responses induced after vaccination against RSV, we constructed recombinant HRØ24 carrying antigenic site Ø, site II (A1) and site IV (A2) of RSV F protein inserted between HRN and HRC regions to mimic the natural trimeric conformation of RSV F protein. Humoral immunologic responses against HRØ24, FIRSV, sites Ø, II, and IV as well as protective efficacy of these recombinant HRØ24 were evaluated in mice. Using this approach, we demonstrated the characteristics of the immune response and the mechanisms of protection.

備註

本會(收文號1120043775)同意該校112年7月7日校研發 字第1120058666號函申請終止維護專利(國立臺灣大學)

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