由紅果椌木半日花烷製備降龍涎香醚及由紅果椌木製備新穎二萜類化合物Preparation of Ambrox form Labdanes of Dysoxylum hongkongense,and the Preparation of New Diterpenoids form Dysoxylum hongkongense

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/548,374

專利證號

US 9,260,404 B1

專利獲證名稱

由紅果椌木半日花烷製備降龍涎香醚及由紅果椌木製備新穎二萜類化合物Preparation of Ambrox form Labdanes of Dysoxylum hongkongense,and the Preparation of New Diterpenoids form Dysoxylum hongkongense

專利所屬機關 (申請機關)

國立臺灣大學

獲證日期

2016/02/16

技術說明

本發明揭示由紅果椌木（Dysoxylum hongkongense）枝葉萃取出的八種二萜類化合物，即Dysongenesins A至H，以一連串化學反應由Dysongensin A製備出可應用於香水產業的降龍涎香醚，以及測定Dysongensins A至H抗人類癌症細胞株的細胞毒殺作用與其抗病毒及抗發炎活性。因此，本發明由Dysongensin A製備降龍涎香醚提供了做為香水產業的香料的新管道，且新穎的二萜類化合物可用於製備抗病毒、抗發炎或抗癌的藥物組合物及/或藥物。 The present invention discloses eight novel diterpenoids, i.e. Dysongensins A to H, extracted from the leaves and twigs of Dysoxylum hongkongense, wherein AMBROX® which is applicable in perfume industry is prepared from Dysongensin A via a series of chemical reactions, and cytotoxicity of Dysongensins A to H against human cancer cell lines and their antiviral and anti-inflammatory activities are determined. Therefore, in the present invention, AMBROX® prepared from Dysongensin A affords a new idea for applying as an odorous compound in perfume industry, and the novel diterpenoids can be prepared as a pharmaceutical composition and/or a drug having antiviral, anti-inflammatory and/or anti-cancer activity.

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