REFINED PRODUCT OBTAINED FROM RICE HULLAND PREPARATION PROCESS AND USE THEREOF

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/831,275

專利證號

US 10,376,577 B2

專利獲證名稱

REFINED PRODUCT OBTAINED FROM RICE HULLAND PREPARATION PROCESS AND USE THEREOF

專利所屬機關 (申請機關)

中國醫藥大學

獲證日期

2019/08/13

技術說明

本研究主要目的是開發穎殼多醣成為具調節免疫功能的健康食品。我們確認穎殼多醣主要成分是第二型阿拉伯半乳聚醣，已建立穎殼阿拉伯半乳聚醣的酵素免疫分析定量方法。另外，也確認穎殼阿拉伯半乳聚醣能刺激自然殺手細胞的毒殺作用，及增進巨噬細胞的吞噬作用。防癌及抗感染是最終產品重要的訴求，已確認穎殼阿拉伯半乳聚醣具有抑制腫瘤細胞成長的效果。我們也將以活體內、及體外試驗探討穎殼阿拉伯半乳聚醣增強巨噬細胞的吞噬作用。 The aim of this study is to develop the polysaccharide from rice hull (RHPS) to be a functional food with immunomodulatory properties. We have confirmed the major polysaccharide of rice hull was a type-II arabinogalactan (AGRH). The enzyme-linked immunosorbent assay for AGRH has also been established. In addition, AGRH was demonstrated that could stimulate NK cell cytotoxicity (against YAC-1 target), and macrophage phagocytosis (against E. coli). Both cancer prevention and anti-infective function are the major claims for the commercial product of RHPS. We had confirmed that AGRH could inhibit the growth of tumor cell in mice. we will also investigate the activities for enhancing phagocytosis in macrophage by AGRH in vivo and in vitro.

備註

連絡單位 (專責單位/部門名稱)

產學合作處生物科技發展育成中心

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(04)2205-3366轉1581

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