藉由一涉及量身訂作的表觀基因體修飾的方法來治療一與異常的基因低度甲基化有關聯的疾病或病況TREATMENT OF A DISEASE OR A CONDITION ASSOCIATED WITH ABERRANT GENE HYPOMETHYLATION BY A METHOD INVOLVING TAILORED EPIGENOMIC MODIFICATION

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

12/135,565

專利證號

US 9,023,819 B2

專利獲證名稱

藉由一涉及量身訂作的表觀基因體修飾的方法來治療一與異常的基因低度甲基化有關聯的疾病或病況TREATMENT OF A DISEASE OR A CONDITION ASSOCIATED WITH ABERRANT GENE HYPOMETHYLATION BY A METHOD INVOLVING TAILORED EPIGENOMIC MODIFICATION

專利所屬機關 (申請機關)

國立中正大學

獲證日期

2015/05/05

技術說明

本發明揭示一種用於治療一個體的方法，該個體具有或被懷疑具有一與該個體之ㄧ或多個基因的異常低度甲基化(aberrant hypomethylation)有關聯的疾病或病況，該方法涉及該個體之一量身訂作的表觀基因體修飾(tailored epigenomic modification)，該修飾使用針對該個體中的低度甲基化基因之經甲基化的聚核酸。 本發明亦揭示一種用於治療一個體的醫藥組成物，該個體具有或被懷疑具有一與該個體之ㄧ或多個基因的異常低度甲基化有關聯的疾病或病況，該組成物包括針對該個體中的低度甲基化基因之經甲基化的聚核酸，俾以在投藥之時引起該個體之一量身訂作的表觀基因體修飾。 Disclosed herein is a method for treating a subject having or suspected of having a disease or condition associated with aberrant hypomethylation of one or more genes in the subject, the method involving a tailored epigenomic modification of the subject using methylated polynucleotides directed to hypomethylated genes in the subject. Also disclosed herein is a medicinal composition for treating a subject having or suspected of having a disease or condition associated with aberrant hypomethylation of one or more genes in the subject, the composition including methylated polynucleotides directed to hypomethylated genes in the subject, so as to result in a tailored epigenomic modification of the subject upon administration.

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