基因多型性用於近視的診斷和藥物發展標誌Using genetic polymorphisms of the BICD1 gene as a method for diagnosing and treating myopia

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

12/180,820

專利證號

US 7,906,289 B2

專利獲證名稱

基因多型性用於近視的診斷和藥物發展標誌Using genetic polymorphisms of the BICD1 gene as a method for diagnosing and treating myopia

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2011/03/15

技術說明

本發明係提供一種利用BICD1基因來檢測近視及/或近視相關併發症的方法。本發明之方法包括由一個體中獲得一生物樣本，檢測此生物樣本中BICD1基因之至少一種SNP基因型，其中此SNP基因型的存在顯示該個體具近視感受性。此SNP基因型係擇自下到所組成之族群：SNPs rs7966276、rs1151029、rs2650122及rs10771923。此外，本發明更提供一種篩選治療或抑制近視物質的方法，以及一種評估一個體對於近視治療藥物反應的方法。 Using the BICD1 gene as a marker for diagnosing myopia and/or myopia related complications is provided. The method includes obtaining a biological sample from a subject, and determining at least one SNP genotype in the BICD1 gene in the biological sample, wherein the presence of the SNP genotype indicates that the subject is susceptible to myopia. The SNP genotype is selected from the group consisting of SNPs rs7966276, rs1151029, rs2650122, and rs10771923. In addition, the present invention also provides a method of screening a material for preventing, treating myopia, and a method of assessing a subject for probability of response to a myopia therapeutic agent.

備註

連絡單位 (專責單位/部門名稱)

智財保護與科技管理組

連絡電話

07-3138030

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