ORAL DRUG COMPOSITION AND USE THEREOF

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

16/810,983

專利證號

US 11,278,630 B2

專利獲證名稱

ORAL DRUG COMPOSITION AND USE THEREOF

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2022/03/22

技術說明

本發明提供一種口服藥物傳遞系統，其包含仿生礦化載體以及酵母膠囊。前述仿生礦化載體包含金屬有機骨架和生物大分子，金屬有機骨架具有一內部空間，生物大分子被包覆於金屬有機骨架之內部空間中。而前述酵母膠囊裝載仿生礦化載體。藉此，本發明之口服藥物傳遞系統可保護其中所包覆的生物大分子抵抗胃腸道中的pH值變化和蛋白酶，使所包覆的生物大分子維持活性，並可靶向腸道的微皺褶細胞，使本發明之口服藥物傳遞系統以膜吞噬模式有效地跨上皮運輸以突破黏膜屏障。 The invention relates to an oral drug delivery system including a biomimetic mineralized carrier and a yeast capsule. The biomimetic mineralized carrier includes a metal-organic framework and a biological macromolecule, in which the metal-organic framework has an internal space, and the biological macromolecule is coated in the internal space of the metal-organic framework. The yeast capsule is loaded with the biomimetic mineralized carrier. Therefore, the oral drug delivery system can protect the biological macromolecule coated therein against pH changes and proteases in the gastrointestinal tract, and maintain activity of the biological macromolecule coated therein. In addition, the oral drug delivery system can target microfold cells of the intestinal tract, allowing the oral drug delivery system of the present invention to effectively transport allowing the oral drug delivery system of the present invention to effectively transport across the intestinal epithelium in a membrane phagocytic mode to break through the mucosal barrier.

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