六碳醣衍生物之製備方法

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

096138949

專利證號

I 345569

專利獲證名稱

六碳醣衍生物之製備方法

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2011/07/21

技術說明

一鍋化保護反應製備各種不同單醣建構單元及一鍋化醣鏈結反應合成寡醣。 One aspect of the present invention provides a method for preparing hexose derivatives with highly regioselective scheme to protect individual hydroxyls of monosaccharide units and install an orthogonal protecting group pattern in a one-pot manner. A method for preparing hexose derivatives according to this aspect of the present invention comprises the steps of providing a silylated hexose, treating the silylated hexose with a first carbonyl compound in the presence of a catalyst to form an ketalized hexose, treating the ketalized hexose with a second carbonyl compound followed by treating with a first reductant to form an etherized hexose, and converting the etherized hexose into a target hexose derivative. The present method may treat the etherized hexose with silylate-removing reagent to form a 2-alcohol hexose. Furthermore, the present method may treat the etherized hexose with an electrophile under basic conditions to form a fully protected glycoside and then treat the fully protected glycoside with an oxidant to form a 3-alcohol hexose. In addition, the present method may treat the etherized hexose with an anhydride followed by treating with an acid and a second reductant to form a 4-alcohol hexose, or treating the ...

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