含鎳超氧化物岐化酶擬態化合物及其衍生物用於預防及治療神經退化性疾病的用途

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

104102742

專利證號

I 534150

專利獲證名稱

含鎳超氧化物岐化酶擬態化合物及其衍生物用於預防及治療神經退化性疾病的用途

專利所屬機關 (申請機關)

國立臺灣師範大學

獲證日期

2016/05/21

技術說明

在神經退化性疾病中，不正常的蛋白堆積會誘發氧化壓力的上升而導致細胞死亡。因此，抑制不正常蛋白的堆積和降低氧化壓力或減少活性氧物質（ROS）被認為可壓制衍生的下游傷害機制，且對神經退化性疾病，如小腦萎縮症（SCA）、阿茲海默症（AD）或巴金森氏症（PD），提供具有潛力的預防和治療方針。本發明利用含鎳超氧化物岐化酶擬態化合物及其衍生物，針對小腦萎縮症、阿茲海默症及巴金森氏症建立數個細胞及動物實驗。各項實驗結果皆可顯示含鎳超氧化物岐化酶之擬態化合物及其衍生物在抑制不正常蛋白堆積及降低氧化壓力或減少活性氧物質的實際作用，此外，這些實際作用經由小腦萎縮症基因轉殖（SCA17）小鼠和阿茲海默症小鼠的海馬迴切片培養、巴金森氏症大鼠的大腦組織免疫化學染色以及SCA17小鼠、阿茲海默症小鼠和巴金森氏症大鼠得以證實。 The accumulation of abnormal proteins in neurodegenerative disorders is considered to induce oxidative stress and lead to cell death. Thus suppression of abnormal protein aggregation and reducing oxidative stress or reactive oxygen species (ROS) are expected to inhibit a wide range of harmful downstream events, providing an observation for identifying the potential prevention and treatment of neurodegenerative disorders comprising spinocerebellar ataxia (SCA), Alzheimer’s disease (AD) or Parkinson’s disease (PD). In the present invention, there are several cell and animal experiment models for SCA, AD and PD established, and NiSOD-like compounds were applied to these experiment models. The results have demonstrated how NiSOD-like compounds are likely to work in suppressing abnormal protein aggregation and reducing oxidative stress and confirmed with brain slice culture of SCA17 transgenic mice and AD mice, brain tissues immunostaining of PD mice, and SCA17 transgenic, AD and PD mice.

備註

連絡單位 (專責單位/部門名稱)

產學合作組

連絡電話

77341329

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