5（9-ㄚ啶胺基）甲苯胺化合物

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

10/630,343

專利證號

US6821983

專利獲證名稱

5（9-ㄚ啶胺基）甲苯胺化合物

專利所屬機關 (申請機關)

中央研究院

獲證日期

2004/11/23

技術說明

新抗癌藥物, 5-(9-Acridinylamino)toluidine衍生物,在試管中對許多人類癌細胞生長有顯 著抑制作用,具廣效性. 其中以BO-0723, BO-0724及BO-0777在裸鼠體內之人類乳癌MX-1有非 常顯著的抑制作用,本新研發之化合物在新抗癌藥物對研發具有很高的研發潛力. The newly invented anticancer agents, 5-(9-acridinylamino)toluidine derivatives, exhibited broad spectrum of antitumor activity against a variety of human tumor cell growth in vitro. Among these compounds, BO-0723, BO-0724, and BO-0777 possessed significant antitumor efficacy in nude mice bearing human breast tumor MX-1 xenograft. These agents were also not cross-resistant with taxol or vinblastine. Thus, the newly invented agents have high potential to be developed as a new and effective agent for cancer chemotherapy.

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