經修飾纖維黏連蛋白片段或變體及其用途Modified fibronectin fragments or variants and uses thereof

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

102120488

專利證號

I 580692

專利獲證名稱

經修飾纖維黏連蛋白片段或變體及其用途Modified fibronectin fragments or variants and uses thereof

專利所屬機關 (申請機關)

國立成功大學

獲證日期

2017/05/01

技術說明

人類纖維黏蛋白第十個第Ⅲ型域（10Fn3）與第九及十個第Ⅲ型域（9-10Fn3）變異體及其醫藥用途。人類纖維黏蛋白變異體包含胜肽，其具有拮抗組合蛋白αvβ3或α5β1受體活性，該變異體可有效治療和/或預防哺乳類動物與αvβ3或α5β1整合蛋白相關之疾病。上述疾病包含骨質疏鬆症、骨腫瘤或骨癌生長、與血管生成相關之腫瘤生長及癌細胞轉移、骨骼中之腫癌轉移、惡性腫瘤引起之高血鈣症、與血管生成相關之眼部疾病、派傑氏症（Paget’s disease）、風濕性關節炎及退化性關節炎。與血管生成相關之眼部疾病包含老年性黃斑病變、糖尿病視網膜病變、角膜神經血管增生病變、局部缺血導致之神經血管增生視網膜病變、高度近視及早熟性視網膜病變。 Human fibronectin fragments and/or variants thereof as specific antagonists for integrins, in particular integrins αvβ3 and α5β1, as well as their pharmaceutical uses thereof are disclosed. Human fibronectin fragments and/or variants include isolated polypeptides that have integrins αvβ3 or α5β1 activity. The peptides are useful for treatment and/or prevention of integrins αvβ3 or α5β1-associated diseases in a mammal, which include osteoporosis, bone tumor or cancer growth, angiogenesis-related tumor growth and metastasis, tumor metastasis in bone, malignancy-induced hypercalcemia, angiogenesis-related eye diseases, Paget’s disease, rheumatic arthritis, and osteoarthritis. The angiogenesis-related eye diseases include age-related macular degeneration, diabetic retinopathy, corneal neovascularizing diseases, ischaemia- induced neovascularizing retinopathy, high myopia, and retinopathy of prematurity.

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