MAGNETIC BEAD-BASED DIGITAL MICROFLUIDIC IMMUNOANALYSIS DEVICE AND METHOD THEREOF

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/738,942

專利證號

US 9,746,465 B2

專利獲證名稱

MAGNETIC BEAD-BASED DIGITAL MICROFLUIDIC IMMUNOANALYSIS DEVICE AND METHOD THEREOF

專利所屬機關 (申請機關)

國立交通大學

獲證日期

2017/08/29

技術說明

一種磁珠式數位微流體免疫分析裝置與其方法，包括一下板、配置於下板的上方的一上板、配置於上板與下板之間的一分隔結構、以及配置於上板或下板上的一磁鐵。下板包括一第一電極層，其包括尺寸不一致的多個通道電極。含有少數磁珠的一液滴配置於下板上，並對應於通道電極。磁鐵以藉由一磁力吸引磁珠趨向通道電極中尺寸較小者，而當一電壓施加於第一電極層時，液滴藉由一雙向介電濕潤力切割成含有磁珠的一檢測部分與不含磁珠的一廢液部分分別對應於通道電極中尺寸較小者與較大者。 A magnetic bead-based digital microfluidic immunoanalysis device and a method thereof are provided, which includes a lower plate, an upper plate disposed above the lower plate, a separating structure therebetween and a magnet disposed on the upper plate or the lower plate. The lower plate includes a first electrode layer including a plurality of channel electrodes with different sizes. A droplet with few magnetic beads is disposed on the lower plate and corresponding to the channel electrodes. The magnet attracts the magnetic beads to approach to the smaller one of the channel electrodes though a magnetic force, and when a voltage is applied to the first electrode layer, the droplet is divided to a detection portion with the magnetic beads and a waste-liquid portion without the magnetic beads respectively corresponding to the smaller one and the larger one of the channel electrodes through a dual-direction electrowetting-on-dielectric force.

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