使用油醯基乙醇醯胺來治療癌症TREATMENT OF CANCER WITH OLEOYLETHANOLAMIDE

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

100149822

專利證號

I 432189

專利獲證名稱

使用油醯基乙醇醯胺來治療癌症TREATMENT OF CANCER WITH OLEOYLETHANOLAMIDE

專利所屬機關 (申請機關)

中國醫藥大學

獲證日期

2014/04/01

技術說明

Acylethanolamides(AEs)為一廣泛富含於腸道細胞表面的脂質，其中包括endocannabinoid anandamide (AEA), palmitoylethanolamide (PEA) 及 Oleoylethanolamide (OEA)。本申請書中証實油醯基乙醇醯胺OEA除了可以抑制人類癌細胞(包括人類肺癌、結腸直腸癌、乳癌、肝癌、口腔癌、胃癌細胞)生長外，同時與維生素A、類胡蘿蔔素、ω-3多不飽和脂肪酸、ω-6多不飽和脂肪酸、共軛次亞麻油酸協同作用時，可以當作細胞敏感因子，協同增加人類癌細胞細胞週期停滯與死亡，而其主要分子機制為藉由促進G1細胞週期停滯與細胞凋零死亡的途徑，因此OEA可以當作癌症預防與治療的有效化合物。 Oleoylethanolamide (OEA) is one of the ethanolamide lipids in cellular membrane of gastrointestinal tract. However, the inhibitory effects of OEA and lycopene on the proliferation of human colon cancer cells have not been demonstrated yet. Therefore, the present study investigated whether supplementation of OEA and lycopene would help prevent tumor growth and progression in both in vitro cell study and in vivo animal model of CRC. The results demonstrated that OEA and lycopene synergistically inhibited the proliferation of human colon cancer HT-29 cells in vitro. OEA and lycopene significantly induced cell cycle arrest at G1 phase in vitro. OEA and lycopene augmented the programmed cell death. These results demonstrated novel anti-cancer effects of OEA in the suppression of tumor growth and progression of CRC in both in vitro and in vivo models.

備註

本部(發文號1100007434)同意貴校110年1月28日明產字第1100001067號函申請終止維護專利。(中國醫)

連絡單位 (專責單位/部門名稱)

產學合作處生物科技發展育成中心

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