懸滴裝置、形成懸滴之方法以及利用懸滴培養細胞之方法

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

110106799

專利證號

I 760120

專利獲證名稱

懸滴裝置、形成懸滴之方法以及利用懸滴培養細胞之方法

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2022/04/01

技術說明

本發明提供一種懸滴裝置，其包含一懸滴盒及一負壓模組。懸滴盒包含一底盤及一上蓋，上蓋與底盤結合並共同界定出一壓力腔，上蓋具有相對的一頂面及一底面，頂面凹設有複數個槽，各個槽以一通孔連通壓力腔，且所述槽係用以容置液體。負壓模組連通壓力腔，且用以使壓力腔呈負壓，進而使各個槽中的液體通過通孔，並形成懸滴垂掛於上蓋的底面。藉由操控負壓模組，可以快速驅使槽中的液體形成懸滴，大幅增加便利性及效率，無須花費過多成本，此外，利用本發明的懸滴裝置所形成的懸滴各自獨立，降低懸滴之間相互汙染的可能性。 A hanging drop device is provided in the present disclosure. The hanging drop device includes a hanging drop box and a negative pressure module. The hanging drop box includes a plate and a cover being coupled with the plate to delimit a pressure chamber. The cover includes an upper surface and a bottom surface opposite to the upper surface, and a plurality of wells is recessed from the upper surface. Each well is communicated with the pressure chamber through a hole, and is for containing liquid. The negative pressure module is communicated with the pressure chamber and generates a negative pressure in the pressure chamber. Therefore, the liquid in each well is driven to pass through the hole and forming a hanging drop hanging from the bottom surface of the cover. By operating the negative pressure module, it is able to make the liquid in the wells form the hanging drops rapidly, which significantly increases convenience and efficiency without excess cost. Moreover, the hanging drops formed by the hanging drop device of the present disclosure are independent of each other, reducing the possibility of contamination happening between the hanging drops.

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