Method for detecting cardiovascular disease biomarker

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

15/277,563

專利證號

US 10,107,824

專利獲證名稱

Method for detecting cardiovascular disease biomarker

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2018/10/23

技術說明

本發明涉及以場效電晶體偵測心血管疾病指標的方法，其中是以高電子遷移率電晶體(High Electron Mobility Transistor，HEMT)藉由免疫分析法(immunoassay)以偵測樣品中的心血管疾病指標。更詳細而言，是透過配體與受體的交互作用(ligand-receptor interaction)偵測樣品中與心血管疾病相關的生物指標(biomarker)，且心血管疾病相關的生物指標可包括NT-proBNP(N-terminal of the prohormone brain natriuretic peptide，N端前腦利鈉肽)及cTnI(Cardiac Troponin-I，心肌旋轉蛋白I)等。 The disclosure relates to a method for detecting analytes in a liquid sample, more particularly to a method for detecting a cardiovascular disease biomarker in a liquid sample. The concentration of cardiovascular disease (CVD) biomarkers, such as troponin I and NT-proBNP, within human blood samples may be one of potential indices for diagnosis of acute congestive heart failure. Conventional methods for detecting the CVD biomarkers in a liquid sample, such as Enzyme-Linked Immunosorbent Assay (ELISA) and the electrochemical redox method, are often time-consuming and have relatively low sensitivity. Moreover, such CVD biomarkers often exist in samples having relatively high ionic strength, such as human serum, leading to difficulty in detection due to a severe charge-screening effect.

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