低強度脈衝式超音波裝置用於治療及／或預防神經退化性疾病的用途

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

103130608

專利證號

I 615172

專利獲證名稱

低強度脈衝式超音波裝置用於治療及／或預防神經退化性疾病的用途

專利所屬機關 (申請機關)

國立陽明大學

獲證日期

2018/02/21

技術說明

本發明揭露藉由西方墨點法分析可測得，低強度脈衝超音波（LIPUS）的刺激可增加BDNF，GDNF，VEGF及GLUT1蛋白在大鼠腦星狀膠細胞的表現量，而整合蛋白抑制劑（RGD胜肽）減弱LIPUS誘導神經滋養因子表達的能力，因此，LIPUS可通過活化整合蛋白受體訊號傳導促進神經滋養因子的蛋白質表現量。此外，LIPUS刺激可保護細胞對抗鋁毒，氯化鋁的半致死劑量可從3.77增加至6.25 mM。在活體行為實驗，LIPUS能顯著改善鋁誘導的記憶障礙並減少腦損傷。本發明揭露，一種穿顱脈衝超音波能夠增加所有可能對神經退化性疾病的有益作用的神經滋養因子的蛋白表現量。 Here, we report that low-intensity pulsed ultrasound (LIPUS) stimulation increased protein levels of BDNF, GDNF, VEGF, and GLUT1 in rat brain astrocytes as measured by western blot analysis. The data suggest that neurotrophic factor protein levels may be promoted by LIPUS through activation of integrin receptor signaling. In addition, LIPUS stimulation protected cells against aluminum toxicity by increasing the median lethal dose for aluminum chloride (AlCl3) from 3.77 to 6.25 mM. In in vivo behavioral experiments, LIPUS significantly improved cognitive dysfunction and reduced brain damage in aluminum -induced neurotoxicity. The results of this invention disclosure that transcranial LIPUS is capable of enhancing the protein levels of neurotrophic factors, all of which could have beneficial effects against neurodegenerative diseases.

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