發明
中華民國
092116706
196166
毛細管電泳晶片
國立成功大學
2004/02/01
以毛細管電泳進行蛋白質、抗體或基因分離的技術,在生物檢測上是一項十分有效的技術, 目前 已經可以利用微製程技術來取代傳統高成本且費時的製程過程,且因其尺寸的縮小而縮短分 析的 時間。本發明提供一種微電極佈局以改良毛細管電泳箝制作用,並以CFD-ACETM (CFD Research Corporation, Alabama, U.S.A.)商用軟體進行模擬分析。發明內容包括一組箝制電極,可改 變 毛細管內電位分佈。由分析結果看出,本研究之設計,不但增進毛細管電泳的箝制效果,更 簡化 了毛細管電泳的電路設計及電源供應系統,同時達到傳統毛細管電泳的分離效果。 Great progress has been made in improving the integration and increasing the functionality of MEMS-based microfluidic devices for biological and biochemical applications. Capillary electrophoresis (CE) has been implemented into microchip devices, i.e., CE chips, and been applied in biochemistry and biology. Very small sample amount and short separation time have become the greatest advantages for MEMS-based microfluidic device applications in biological and biochemical processes. The present paper proposed the microelectrodes design to pinch down the transverse diffusion of the sample at the injection mode. The present design simplified the electric circuits and improved the performance of the CE microchip. Simulations were performed using CFD-ACETM (CFD Research Corporation, Alabama, U.S.A.) run on a personal computer.
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