螢光金氣泡醫用對比劑Medical Contrast Agent Made of Microbubbles Containing Fluorescent Gold Nanoclusters

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/468,355

專利證號

US 9,523,032 B2

專利獲證名稱

螢光金氣泡醫用對比劑Medical Contrast Agent Made of Microbubbles Containing Fluorescent Gold Nanoclusters

專利所屬機關 (申請機關)

中原大學

獲證日期

2016/12/20

技術說明

本技術主要針對醫用對比劑之設計製造提供新穎快速製造方法, 主要利用近紅外光發光之螢光金奈米團簇,在高濃度血清蛋白中加入高強度超音波,快速形成微氣泡結構,該結構相當適用於超音波影響顯影,亦可整合其他奈米材料(量子點,氧化鐵奈米粒子,奈米金)形成多模態超音波顯影劑, 該種蛋白做為對比劑(微\奈米氣泡)的外殼，表面嵌有螢光金奈米粒子，增加其對比劑使用範圍，可涵蓋超音波、X光、電腦斷層掃描(CT)、微電腦斷層掃描(Micro CT)、體內近紅外光造影(IVIS)、共軛交螢光顯微鏡(confocal)等能夠比擬X光、聲光或有螢光功能之相關生醫設備。 A Multi-functional contrast agent was developed for clinical and biomedical imaging. The microbubble contrast agent was made up of proteins shell including fluorescent gold nanoclusters. The complex microbubble structure was fabricated by using high-intensity ultrasound. Other nanomaterials such as quantum dots, iron oxide nanoparticles, nanogold can also be included in the sell by using the sonochemical methods. The possible biomedical imaging includes ultrasound, X-ray, computed tomography(CT), micro computed tomography(Micro CT), Image Visualization and Infrared Spectroscopy (IVIS) and confocal,etc.

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