微流道晶片及其使用方法MICROFLUIDIC CHIP AND METHOD USING THE SAME

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

12/776,210

專利證號

US 8,759,096 B2

專利獲證名稱

微流道晶片及其使用方法MICROFLUIDIC CHIP AND METHOD USING THE SAME

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2014/06/24

技術說明

本發明提供一種微流道晶片及其使用方法。微流道晶片包括一基材，具有一表面；至少一組織培養區，形成於基材之表面，組織培養區具有一微流道，係由複數個具有預定深度之幾何形結構所連接形成(噴嘴型結構)，微流道具有一輸入口與一輸出口，分別位於微流道之兩端以供培養液之輸入及輸出，並在微流道底部開設有至少一氣體交換孔。利用此種微流道晶片進行體外組織的培養，可降低邊界流速及應力，有效延長體外組織如肝臟組織的培養存活時間。 Disclosed is a microfluidic chip and method using the same. The microfluidic chip comprises a substrate having a surface, and at least a tissue culture area is formed on the surface of the substrate. The tissue culture area has a microfluidic channel formed by a plurality of connected geometrical structures (nozzle structures) having a determined depth. The microfluidic channel has an inlet and an outlet, which are at two ends of the microfluidic channel, for medium inputting and outputting, respectively. Additionally, at least an air-exchange hole is formed on the bottom of the microfluidic channel. By using the microfluidic chip for tissue culture, lateral flow speeds and strains can be decreased, so as to prolong lifetime of tissues such as liver tissues.

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