一種苯酞類化合物用於製備替代/輔助高壓氧療法改善組織缺氧之醫藥組合物的用途/METHOD FOR ENHANCING THE OXYGENATION LEVEL OF TISSUE CELLS AS AN ALTERNATIVE METHOD FOR HYPERBARIC OXYGEN THERAPY

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

15/071,186

專利證號

US 9,937,150 B2

專利獲證名稱

一種苯酞類化合物用於製備替代/輔助高壓氧療法改善組織缺氧之醫藥組合物的用途/METHOD FOR ENHANCING THE OXYGENATION LEVEL OF TISSUE CELLS AS AN ALTERNATIVE METHOD FOR HYPERBARIC OXYGEN THERAPY

專利所屬機關 (申請機關)

國立中山大學

獲證日期

2018/04/10

技術說明

傳統高壓氧療法是將病人置於高壓艙內，艙內加壓並維持在2.0-3.0大氣壓下，並使人經由氧氣面罩吸100% 之氧氣，以提高血中含氧濃度，改善組織缺氧及促進傷口癒合。然而，高壓氧療法由於使受施者在高壓下吸入高濃度的氧氣，組織間快速壓力改變,可能造成相當多的副作用，包括氣壓傷、減壓病及氧中毒等。若操作不當甚至有致命的風險。本發明提出一種可以取代傳統高壓氧療法提升組織含氧濃度的藥物。藉由改變血紅蛋白之氧合平衡曲線，本發明之藥物可以在不改變氧分壓的狀態下達到提升組織細胞中血氧量及改善組織缺氧之功效，可以避免現有高壓氧療法之缺點。 This invention includes using the hydrid treatment of three different types of chemical compounds to facilitate the oxygen release in human hemoglobin and to treat the disease and syndromes associated with the dysfunction of blood circulation. The three types of compounds exhibit specific molecular structure characters, thus distinct chemical properties. The combination of the three types of compounds promotes the oxygen release function by interacting with the hemoglobin macromolecule via three different key active sites to stabilize a specific allosteric conformation of hemoglobin. This hydrid treatment can be used to treat or alleviate thalassemia, hypertension, cardiovascular diseases, migraines and pains associated with menstrual disorders.

備註

連絡單位 (專責單位/部門名稱)

產學營運及推廣教育處

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(07)525-2000#2651

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