應用於抑制/治療腫瘤的磁性奈米藥物MAGNETIC NANOMEDICINE FOR TUMOR SUPPRESSION AND THERAPY

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

13/166,450

專利證號

US 8,329,222 B1

專利獲證名稱

應用於抑制/治療腫瘤的磁性奈米藥物MAGNETIC NANOMEDICINE FOR TUMOR SUPPRESSION AND THERAPY

專利所屬機關 (申請機關)

長庚大學

獲證日期

2012/12/11

技術說明

本發明提供一可抑制/治療人類惡性腫瘤 (如：膀胱癌、乳癌、惡性淋巴瘤、軟組織肉瘤、胃癌、肺癌等) 之磁性奈米藥物，此藥物以磁性奈米四氧化三鐵為核，以羧基化聚苯胺高分子為殼，殼外以共價鍵接上抗膀胱腫瘤藥物泛艾黴素 (Epirubicin 和 Doxorubicin) 而成，簡稱為EPI/SPAnH/MNPs 和 DOX/SPAnH/MNPs。本發明提出的磁性奈米藥物，不僅可明顯提升藥物之穩定性，由於此新藥可以均勻的分散於水中，加上此磁性奈米藥物具有超順磁特性，可藉由外加磁場將藥物導引集中於特定部位，增加局部治療濃度。由體外毒性測試可知，本發明之磁性奈米藥物 EPI/SPAnH/MNPs 和 DOX/SPAnH/MNPs 在有效藥量10 M、磁場 800 Gauss 條件下，對人類膀胱腫瘤細胞 MGH-U1 的毒殺率都較純的泛艾黴素好，分別增加約 20.4 % 和 22.6 %，具經濟競爭力。 關鍵字：磁性奈米粒子、超順磁性、泛艾黴素、膀胱腫瘤。 This investion provides the novel magnetic nanodrugs comprise a magnetic nanoparticle of Fe3O4 (MNPs) overcoated with a layer of carboxy-functionalized polyaniline (SPAnH) and an anti-prostate cancer drug Epirubicin (EPI) or Doxorubicin (DOX) which is covalently bonded with the shell of SPAnH to EPI/SPAnH/MNPs and DOX/SPAnH/MNPs. The thermal stability of EPI/SPAnH/MNPs is much better than that of EPI. This nanodrug is water solvable and can be dispersed uniformly in water. In comparison with EPI (or DOX), the in vitro cytotoxicity tests of this magnetic nanodrug with the concentrations of 10 M and the applied magnetic field of 800 G show that the killing rates of prostate cancer cell (MGH-U1) are increased 20.4 % and 22.6 %, respectively. This result implicates that the magnetic nanodrug has a great economic advantage. Key word：magnetic nanodrug, superparamagnetic, Epirubicin, Doxorubicin, prostate cancer

備註

本部(收文號1090025673)同意該校109年5月4日長庚大字第1090050033號函申請終止維護專利(長庚大)

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