一種檢測卵巢癌的方法Method for the diagnosis of the presence of an ovarian cancer

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

13/044,289

專利證號

US 9,200,262 B2

專利獲證名稱

一種檢測卵巢癌的方法Method for the diagnosis of the presence of an ovarian cancer

專利所屬機關 (申請機關)

臺北醫學大學

獲證日期

2015/12/01

技術說明

目前在所有婦科的癌症中，卵巢癌是佔第二位高死亡率的癌症，尤其當癌轉移至其他的組織或器官時。因此，初期準確地診斷是提高卵巢癌患者存活率的不二法則。目前在臨床上所用的CA125標的蛋白普遍被認為可以用來當作卵巢癌的標記以及可以被用來追蹤卵巢癌的疾病的進展。然而，此標的蛋白欠缺高度專一性，因為較高的CA125蛋白偽陽性反應也常見於其他疾病。因此，造成在準確診斷卵巢癌上相當的困擾。我們利用嗜菌體展現系統從卵巢癌病人腹水中的抗體篩選到一個與卵巢癌相關的標的蛋白，OVTA-1 (QSK)。在臨床病理學的研究，我們發現此蛋白表現和卵巢癌惡化有相當的關連性。除此之外，我們也更進一步確認此蛋白在卵巢腫瘤之生成與轉移所扮演相當重要的角色。 Ovarian cancer is the second leading cause of death in gynecological cancers. However,no any reliable tumor marker is available for detection of this malignant disease at present. CA125 antigen is currently considered as a common clinical marker and used to monitor disease progression for ovarian cancer. However, lack of tumor-specificity is the major problem of CA125 in its clinical applications. In this study, we have screened potential ovarian tumor-associated antigens using phage display technology and identified one gene highly associated with its tumorigenesis. This gene is so-called ovarian tumor antigen-1 (OVTA-1 (QSK)). In this application, we first correlated between clinical outcomes of patients with ovarian cancer and OVTA-1 expression in the cancer. Subsequently, its pivotal role in tumorigenesis and tumor metastasis of ovarian cancer was further demonstrated in both in vitro and in vivo studies.

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