具修飾側鏈之RNA病毒衍生胜肽及其用途RNA VIRUS-DERIVED PEPTIDES WITH MODIFIED SIDE CHAINS

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

13/440,101

專利證號

US 8,524,659 B2

專利獲證名稱

具修飾側鏈之RNA病毒衍生胜肽及其用途RNA VIRUS-DERIVED PEPTIDES WITH MODIFIED SIDE CHAINS

專利所屬機關 (申請機關)

國立臺灣大學

獲證日期

2013/09/03

技術說明

本發明提供一種具修飾側鏈之RNA病毒衍生胜肽，其能藉由調整側鏈長短或電性而修飾胜肽側鏈，而使此胜肽對RNA病毒具高親和力並有優異的細胞穿越能力。本發明亦提供一種以抑制RNA病毒之醫藥組合物，利用前述RNA病毒衍生胜肽的高親和力，抑制病毒自我複製，以有效治療RNA病毒相關疾病。本發明另提供一種藥物傳輸之載體，利用前述RNA病毒衍生胜肽的細胞穿越能力，有效地攜帶藥物至欲治療標的，以提高藥物的傳輸及治療效率。 The present invention provides a RNA virus-derived peptide with modified side chains, wherein the side chain of the RNA virus-derived peptide is modified by altering the side chain length or charges thereof such that the RNA virus-derived peptide has a high binding affinity for viral RNA and an excellent cell uptake capability. The present invention also provides a composition for inhibiting RNA virus wherein said RNA virus-derived peptide is used to effectively inhibit viral self-replication and treat related diseases by its high affinity for viral RNA. A drug delivery carrier is also provided, wherein the RNA virus-derived peptide is used to carry desired drugs to the target due to its cell uptake capability and thereby has great drug- delivery and treating efficiency.

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