油體蛋白(oleosin)及修飾型態用於製備安定之新型微脂粒USE OF OLEOSIN AND ITS MODIFIED FORMS IN PREPARING LIPOSOMES WITH HIGH STABILITY

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

102107041

專利證號

I 501786

專利獲證名稱

油體蛋白(oleosin)及修飾型態用於製備安定之新型微脂粒USE OF OLEOSIN AND ITS MODIFIED FORMS IN PREPARING LIPOSOMES WITH HIGH STABILITY

專利所屬機關 (申請機關)

國立中興大學

獲證日期

2015/10/01

技術說明

本研究利用三酸甘油酯、二酸甘油酯、礦物油、Span 80或複合溶劑配方(由油、助溶劑、界面活性劑及輔界面活性劑組成)製備成不同油水型的人造油體，並觀察其穩定性。之後選定穩定性佳的篦麻油與複合溶劑配方形成的油水型人造油體攜帶雌激素，以胃管餵給SD大鼠，再以酵素免疫分析法來偵測雌激素含量，以評估人造油體作為脂溶性藥物傳遞系統的可能性。 　　依新型人造油體配方製備的油體，一樣具有以前人造油體，保護疏水性藥物於磷脂質及蛋白質內部的優點，但能突破以前油體只能溶解攜帶少數疏水性藥物的限制，尤其是複合溶劑配方，能針對特定疏水性藥物而設計配方內容，提高其溶解度，且非DOGP的磷脂質可提供更多製備油體的選擇，而大大增進油體作為藥物傳遞系統的應用性。 Mineral oil, diglyceride, various triglycerides, or lipid formulations containing a surfactant, cosurfactant or solubilizer were used to prepare artificial oil bodies and their stability was observed. Male Sprague-Dawley rats were gavaged by various artificial oil bodies with estradiol, and the level of serum estradiol was determined by EIA to investigate the potential of the artificial oil body as a drug delivery system. The results show that cleocin and phospholipid have the ability to form the artificial oil body with every kind of oil and lipid formulations. The artificial oil body can protect the estradiol from degradation and increase the bioavailability. The artificial oil body containing the specific lipid formulation has the best bioavailability, indicating it might be absorbed through the peyer’s patches because of its smaller size and avoid the hepatic first-pass metabolism.

備註

本部(收文號1090023163)同意該校109年4月20日興產字第1094300209號函申請終止維護專利(中興)

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