抑制皮膚色素沉著之組合物及其用途COMPOSITION FOR INHIBITING MELANOGENESIS AND USE THEREOF

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

099105580

專利證號

I 481422

專利獲證名稱

抑制皮膚色素沉著之組合物及其用途COMPOSITION FOR INHIBITING MELANOGENESIS AND USE THEREOF

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2015/04/21

技術說明

在本發明中，我們利用活體外與活體內兩種方式來測有效果而不會造成細胞毒殺的皮膚黑色素沉著之抑制劑。從研究成果可以得知，自香桂(Cinnamomum subavenium)莖部分可以離出一些純化合物，其中兩種—Linderanolide B和subamolide A在低劑量時，在人類皮膚黑色素細胞及斑馬魚系統便具有良好的抑制黑色素生成效果。從生物活性測試得知linderanolide B和subamolide A具有抗酪胺酸酶活性之特質，顯示其能用在醫療粧品上之潛力。就我們所知，本篇為第一個探討香桂中Linderanolide B與subamolide A兩化合物的生物活性之研究。 Tyrosinases are known to be the first two rate-limiting enzymes in the synthesis of melanin pigments responsible for coloring skin, hair and eyes. We evaluated the skin pigmentation inhibitor effects with both in vitro and in vivo systems to find skin whitening agent. Linderanolide B and subamolide A were isolated from the stems of Cinnamomum subavenium. These two herbal compounds were proved with good pigmentation inhibitory abilities and showed free cytotoxicities at low doses to human skin melanocytes and zebrafish systems. The results obtained from biological assays showed that linderanolide B and subamolide A possessed anti-tyrosinase properties, which exhibited potential application in medical cosmetology.

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智財保護與科技管理組

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07-3138030

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