CISPLATIN-LOADED MICROBUBBLES, PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER, METHOD FOR PREPARING PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATING CANCER

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

16/434,647

專利證號

US 11,246,945 B2

專利獲證名稱

CISPLATIN-LOADED MICROBUBBLES, PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER, METHOD FOR PREPARING PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATING CANCER

專利所屬機關 (申請機關)

國防醫學院

獲證日期

2022/02/15

技術說明

【中文】 本揭露公開一種治療癌症的方法，包括以下操作。將藥物組合物給予有需要的受試者。藥物組合物包括介質和分散在介質中的複數個裝載順鉑的微氣泡。每個裝載順鉑的微氣泡包括外殼部分和核心部分。外殼部分包括複數個白蛋白分子及複數個與白蛋白分子共價鍵合的第一順鉑分子。核心部分被外殼部分包圍，其中核心部分包括惰性氣體與複數個第二順鉑分子的混合物。然後將超音波能量施加到受試者的腫瘤以破壞裝載順鉑的微氣泡。因此，我們所研發產製的裝載順鉑的白蛋白微氣泡，當與超音波結合進行腫瘤的治療，不僅具有腫瘤抑制的成效，更可顯著減低順鉑相關的腎毒性，深具未來臨床治療的潛力。 【英文】 Disclosed herein is a method for treating a cancer, the method includes following operations. A pharmaceutical composition is administered to a subject in need. The pharmaceutical composition includes a medium and a plurality of cisplatin-loaded microbubbles dispersed in the medium. Each cisplatin-loaded microbubble includes a shell portion and a core portion. The shell portion includes a plurality of albumin molecules and a plurality of first cisplatin molecules covalently bonding to the albumin molecules. The core portion is surrounded by the shell portion, wherein the core portion includes a mixture of inert gas and a plurality of second cisplatin molecules. Ultrasound energy is then applied to a tumor of the subject to break the cisplatin-loaded microbubbles. Therefore, the combination of CDDP-MBs with ultrasound is effective and significantly attenuates CDDP- associated nephrotoxicity, indicating a promising clinical potential for this approach.

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