增強免疫活性之樟芝子實體水萃取物及其製備方法Water extract of Antrodia camphorata for immunostimulatory effect and preparation method thereof

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/577,605

專利證號

US 9,241,962 B2

專利獲證名稱

增強免疫活性之樟芝子實體水萃取物及其製備方法Water extract of Antrodia camphorata for immunostimulatory effect and preparation method thereof

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2016/01/26

技術說明

菇類所產生的多醣體，在現今研究中發現其可成為一種誘使樹突細胞成熟及功能活化的新藥劑。所以，在尋找新的免疫治療藥劑時，於傳統醫學中被應用治療癌症的食藥用真菌被視為極具潛力的候選藥物，其中以樟芝最為國人所知曉。 本發明係提供一種樟芝子實體水萃取物的製備方法，包括下列步驟：(a)研磨樟芝子實體成粉狀；及(b)以水煮、迴流萃取該粉狀的樟芝子實體，過濾及離心，獲得樟芝子實體水萃取物。此富含多醣體的樟芝子實體水萃取物可誘發樹突細胞成熟化，促進T細胞增生及干擾素-gamma的分泌，趨化輔助性T細胞(T helper 1)反應。樟芝子實體水萃取物可有效應用於癌症免疫治療。 In the present researches, polysaccharides produced from this medical mushroom can be new pharmaceuticals for inducing the maturation and activation of dendritic cells. Therefore, when searching for new cancer immunotherapy agents, the edible and medicinal fungi being used for cancer treatment in folk medicine are promising candidates, wherein Antrodia camphorata is the most popular one. A preparation method for a water extract of fruiting bodies of A. camphorata (ACW) is provided. The method includes steps of: (a) grounding the fruiting bodies of A. camphorata into the fine powder; and (b) boiling by reflux extraction, filtering and centrifuging the fine powder to obtain ACW. This polysaccharide- rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and IFN-gamma production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.

備註

連絡單位 (專責單位/部門名稱)

智財保護與科技管理組

連絡電話

07-3138030

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