三維細胞培養與藥物測試篩選的陣列平台

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

110121730

專利證號

I 769861

專利獲證名稱

三維細胞培養與藥物測試篩選的陣列平台

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2022/07/01

技術說明

本發明揭露一種三維細胞培養與藥物測試篩選的陣列平台。於此陣列平台中，水膠-細胞混合物注入區用以注入複數種水膠-細胞混合物。複數個細胞觀察區連接水膠-細胞混合物注入區。該些細胞觀察區之下方均設置有電極，並透過電極對該些細胞觀察區內的該複數種水膠-細胞混合物進行自動的細胞定量及三維細胞共排列，以仿造體內組織的結構。藥物注入區用以注入複數種藥物。複數個藥物組合產生器分別對應於該些細胞觀察區且均連接藥物注入區。該些藥物組合產生器均具有微流道結構且係用以根據該複數種藥物產生複數種藥物組合。 An array platform for three-dimensional cell culturing and drug testing and screening is disclosed. In the array platform, a hydrogel-cell mixture injection area is used to inject kinds of hydrogel-cell mixtures. Cell observation areas are connected to the hydrogel-cell mixture injection area. Electrodes are disposed under the cell observation areas and automatic cell quantification and three-dimensional cell co-arrangement of the kinds of hydrogel-cell mixtures in the cell observation areas through the electrodes to imitate a structure of body's tissues. A drug injection area is used to inject kinds of drugs. Drug combination generators respectively correspond to the cell observation areas and are connected to the drug injection area. The drug combination generators all have micro-flow channel structure and used to generate drug combinations according to the kinds of drugs.

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