蒽醌[2,1-c][1,2,5]噻二唑-6,11-二酮化合物緩解疼痛的應用INDICATION OF ANTHRA[2,1-c][1,2,5] THIADIAZOLE-6,11-DIONE COMPOUND IN ALLEVIATING PAIN

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/487,449

專利證號

US 9,192,602 B2

專利獲證名稱

蒽醌[2,1-c][1,2,5]噻二唑-6,11-二酮化合物緩解疼痛的應用INDICATION OF ANTHRA[2,1-c][1,2,5] THIADIAZOLE-6,11-DIONE COMPOUND IN ALLEVIATING PAIN

專利所屬機關 (申請機關)

國立中央大學

獲證日期

2015/11/24

技術說明

Anthrax[2,1-c][1,2,5]thiadiazole-6,11-dione之前發現具有抗癌功效(Huang et al., 2009; Chang et al 2011), 將此種化合物以皮下注射於小鼠中,可有效抑制pH5.0酸溶液及坐骨神經結紮所引發的機械性痛覺敏感現象。有效劑量為2.2μg/kg。且在治療神經受損所引發慢性疼痛中, Anthrax[2,1-c][1,2,5]thiadiazole-6,11-dione藥效比目前止痛劑gabapentin(3 mg/kg)好。由於Anthrax[2,1-c][1,2,5]thiadiazole-6,11-dione具有抗癌功效,又有止痛效果,對於癌症所引發之慢性疼痛的病人為極佳止痛劑。 Anthrax[2,1-c][1,2,5]thiadiazole-6,11-dione has anti-cancer activity (Huang et al., 2009) (Chang et al 2011). We discovered that Anthrax[2,1-c][1,2,5]thiadiazole-6,11-dione specifically inhibit pain induced by acid-injection and by injury of spinal nerve ligation. The effective doses used for peripheral injection is 2.2μg/kg. The effective doses are lower than the doses of gabapentin (3 mg/kg). Thus Anthrax[2,1-c][1,2,5]thiadiazole-6,11-dione is a better analgesic compound then gabapentin in treatments of neuropathic pain. Anthrax[2,1-c][1,2,5]thiadiazole-6,11-dione has both anti-cancer and analgesic activity. It can be used in the treatment for cancer pain patients.

備註

本會(收文號1120010838)同意該校112年2月21日中大研產字第1121400216號函申請終止維護專利(國立中央大學)

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