早發型帕金森病(D331Y)PLA2G6突變基因嵌入模式與藥物篩選平台和方法

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

108100196

專利證號

I 695891

專利獲證名稱

早發型帕金森病(D331Y)PLA2G6突變基因嵌入模式與藥物篩選平台和方法

專利所屬機關 (申請機關)

長庚醫療財團法人

獲證日期

2020/06/11

技術說明

本發明關於早發型帕金森病之基因檢測模式和篩選用於治療早發型帕金森病的藥物之平台和方法。 Disclosed is a (D331Y) PLA2G6 knockin mouse, which shows similar clinical symptoms to those of patients suffering from Parkinson's disease (PD), and begins to display early-onset cell death of dopaminergic neurons in its substantia nigra (SN), synucleinopathy, and tau pathology at the age of about 6 months, wherein the dopaminergic neurons exhibit mitochondrial structural abnormality and dysfunction. Treatment of the (D331Y) PLA2G6 knockin mice with L-Dopa shows a good response. The (D331Y) PLA2G6 knockin mouse can be used as a platform for developing a mrdicament and method for treating PD.