固化之油體，其製法及其於粉末與錠劑劑型之應用SOLIDIFIED OIL BODIES, THE PRODUCING METHOD, AND THE USE THEREOF IN POWDER AND TABLET DOSAGE

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

101115857

專利證號

I 459976

專利獲證名稱

固化之油體，其製法及其於粉末與錠劑劑型之應用SOLIDIFIED OIL BODIES, THE PRODUCING METHOD, AND THE USE THEREOF IN POWDER AND TABLET DOSAGE

專利所屬機關 (申請機關)

國立中興大學

獲證日期

2014/11/11

技術說明

本發明係關於一種天然及人造油體之固化方法，經過本發明方法固化之油體，在乾燥前與乾燥後皆保持相似的大小及結構完整性，不會發生油體聚結現象，其係藉由將70%以上作為賦形劑之甘露糖醇與油體溶液混合，再進行乾燥程序而成。本發明之固化油體可為天然來源之油體，或是有或無包含欲載負物質的人造油體。經過本發明方法固化之油體，在乾燥前與乾燥後皆保持相似的大小及結構完整性，不會發生油體聚結現象，可應用於粉末或錠劑劑型之製備。 On the basis of testing several excipients, the coalescence of oil bodies could be mostly prevented when they were accompanied with 70% or higher percentage of mannitol. Sizes of oil bodies were found similar under a light microscope before and after solidification in either a powder or a tablet form in the company of 80% mannitol. In the presence of 20% polyethylene glycol, curcumin was homogenously incorporated into sesame oil, and then successfully encapsulated in artificial oil bodies stabilized by recombinant sesame caleosin. Following the same protocol, artificial oil bodies encapsulating curcumin were solidified in the forms of powder and tablet. The curcumin-loaded artificial oil bodies dissolved from the powder or tablet remained stable after an accelerated stress test under a condition of 75% humidity at 40 C for four months.

備註

本部(文號1090000062)同意該校108年12月31日興產字第1084300814號函申請終止維護專利(中興)

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