碟片型免疫磁珠標定微粒體之分離方法及系統

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

098106786

專利證號

I 373617

專利獲證名稱

碟片型免疫磁珠標定微粒體之分離方法及系統

專利所屬機關 (申請機關)

國立臺灣大學

獲證日期

2012/10/01

技術說明

一種碟片型免疫磁珠標定微粒體之分離系統，用以將至少一流體樣本中之至少二種微粒體予以分離，該分離系統包括一碟型載板及一磁吸單元，在碟型載板上形成有至少一組流道結構，其係包括沿碟型載板之幾何中心向外環緣一一配置之一內貯置槽、至少一輔助分離槽及至少一外貯置槽，其分離方法係在將流體樣本貯置於內貯置槽後，藉由碟型載板旋轉產生之離心力使流體樣本流向外貯置槽，流體樣本中標定有免疫磁珠之微粒體受磁吸單元所產生之磁力吸引，留存於內貯置槽或輔助分離槽；未標定有免疫磁珠之微粒體，則隨流體樣本收集至外貯置槽。 Disclosed is a disk based system for separating at least two types of particulates contained in a sample fluid. The system includes a disk-like carrier board and a magnetic attraction unit. The disk-like carrier board forms at least one flow channel structure and reservoir. A method of separation carried out with the system includes introducing the sample fluid into the inner reservoir and then rotating the disk-like carrier board to induce a centrifugal force. The sample fluid contains particulates that are labeled with immunomagnetic beads and the labeled particulates are attracted by the magnetic force generated by the magnetic attraction unit to retain in the inner reservoir or the separation chamber. Particulates not labeled with the immunomagnetic beads and contained in the sample fluid move with the sample fluid to the outer reservoir.

備註

本部(收文號1100033534)同意該校110年6月9日校研發字第1100036312號函申請終止維護專利(台大)

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