雞傳染性鼻炎重組血球凝集素次單位疫苗及其製備與應用方法RECOMBINANT HAEMAGGLUTININ VACCINE FOR INFECTIOUS CORYZA OF CHICKENS, AND METHODS OF PREPARATION AND USE THEREOF

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

100104984

專利證號

I 485246

專利獲證名稱

雞傳染性鼻炎重組血球凝集素次單位疫苗及其製備與應用方法RECOMBINANT HAEMAGGLUTININ VACCINE FOR INFECTIOUS CORYZA OF CHICKENS, AND METHODS OF PREPARATION AND USE THEREOF

專利所屬機關 (申請機關)

國立中興大學

獲證日期

2015/05/21

技術說明

雞傳染性鼻炎，係由 Avibacterium paragallinarum感染所引起，此病又稱為雞傳染性可利查（infectious coryza，簡稱IC），為雞隻最重要細菌性疾病之一。目前台灣地區每年所用之IC疫苗數量皆在億劑以上，顯示其疫苗已被廣泛使用，然而此疾病在雞群中仍持續發生，因此確有必要開發新型疫苗以防治此疾病。本發明揭露雞傳染性鼻炎菌(Avibacterium paragallinarum)之血球血球凝集素蛋白中存在一高度變化區，且以大腸桿菌所生產含此高度變化區序列之重組蛋白可作為有效之疫苗以保護雞隻對抗雞傳染性鼻炎菌之感染。 Infectious coryza (IC), caused by Avibacterium paragallinarum, is one of the most important bacterial diseases of chickens. More than one hundred million doses of IC vaccine have been used in Taiwan annually but the outbreaks of this disease continue to occur. It is thus necessary to develop a new type of vaccine against infectious coryza. This invention discloses that the haemagglutinin protein of Avibacterium paragallinarum contains a hypervariable region and that the E. coli-expressed recombinant protein containing this hypervariable region could serve as an effective vaccine to protect chickens against challenge infection with Av. paragallinarum.

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