AUTOMATIC MICROFLUIDIC SYSTEM FOR RAPID PERSONALIZED DRUG SCREENING AND TESTING METHOD FOR PERSONALIZED ANTIBIOTIC SUSCEPTIBILITY

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

16/251,445

專利證號

US 11,007,524 B2

專利獲證名稱

AUTOMATIC MICROFLUIDIC SYSTEM FOR RAPID PERSONALIZED DRUG SCREENING AND TESTING METHOD FOR PERSONALIZED ANTIBIOTIC SUSCEPTIBILITY

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2021/05/18

技術說明

本發明提供一種自動化快速篩選個人化藥物組合之微流體晶片系統，其包含一微流體晶片。微流體晶片包含流體儲存單元、流體驅動單元、反應單元以及閥門單元。流體驅動單元包含二混合幫浦，各混合幫浦包含二氣動式微幫浦、一混合腔室及一擋片結構。擋片結構設置於混合腔室中並連接於二氣動式微幫浦之間，當二氣動式微幫浦交替啟動時，擋片結構將隨二氣動式微幫浦之運行而偏擺。藉此，本發明之自動化快速篩選個人化藥物組合之微流體晶片系統透過二混合幫浦的設置可精確且有效地進行流體的混合與達成流體定量運輸，並具有優良的臨床應用潛力。 The present disclosure provides an automatic microfluidic system for rapid personalized drug screening including a microfluidic chip. The microfluidic chip includes a fluid storage unit, a fluid driving unit, a reaction unit and a plurality of valve units. The fluid driving unit includes two mixing pumps. Each of the mixing pumps includes two pneumatic micro-pumps, a mixing chamber and a blocking structure. The blocking sheet structure is disposed in the mixing chamber and is connected between the two pneumatic micro-pumps. When the two pneumatic micro-pumps process alternately, the blocking structure will sway alone the process of the two pneumatic micro-pumps. Therefore, by the arrangement of the two mixing pumps, the automatic microfluidic system for personalized drug screening of the present disclosure can accurately transfer fluids quantitatively and then mix the fluids efficiently and has a potential for applying in the clinical application.

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