以金奈米團簇來減緩氧化壓力和/或老化的方法、組合物及用途USE OF GOLD NANOCLUSTERS IN AMELIORATING OXIDATE STRESS AND/OR AGING

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

13/218,625

專利證號

US 9,101,672 B2

專利獲證名稱

以金奈米團簇來減緩氧化壓力和/或老化的方法、組合物及用途USE OF GOLD NANOCLUSTERS IN AMELIORATING OXIDATE STRESS AND/OR AGING

專利所屬機關 (申請機關)

中原大學

獲證日期

2015/08/11

技術說明

本揭示內容為一種以金奈米團簇來減緩培養細胞之氧化壓力和/或老化，或減緩一個體由血管因子或疾病所引起的氧化壓力和/或老化症狀的方法、組合物及用途。本揭示內容之金奈米團簇粒徑約0.1至20奈米， 且較佳是塗覆有二氫硫辛酸之金奈米團簇。本發明是基於意外發現紅光金奈米團簇可以有效地減緩一培養細胞之氧化壓力和/或老化，因此可作為一製劑，以便有效地抵抗或抑制細胞老化，且進一步發展成為一種可治療由血管因子(如，發炎或血管疾病)誘發之氧化壓力和/或老化的藥劑。 Previous studies suggest that aging process and various disease-related degenerative processes are caused, at least, partly by the free-radical oxidative stress and/or the oxidative shift in the thio/disulfide redox state (Beckeamen and Ames, Physiol. Rev. 1998 78:547-581). Oxidative stress has also been implicated as resulted from factors such as inflammation or a vascular disease. Therefore, there exists in this art a need to find an agent which ameliorates the oxidative stress in the contest of aging and various disease conditions including vascular diseases. Accordingly, agent that ameliorates oxidative stress and, thus, aging process, would be a potential candiate for the development of a medicament or pharmaceutical composition for treating such diseases.

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