High-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

12/926,326

專利證號

US 9,643,030 B2

專利獲證名稱

High-intensity focused ultrasound thermal ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof

專利所屬機關 (申請機關)

長庚大學

獲證日期

2017/05/09

技術說明

本技術為提出一整合超音波溫度影像估測與超音波彈性影像之運算核心技術。實驗中藉由一個聚焦式超音波換能器，使用不同功率對於離體組織進行熱燒灼，並以超音波成像系統利用互相關分析法做溫度及彈性估測。實驗後並將組織做樣本切片，並將燒灼後變性的區域大小，經量測後與兩種技術所估測面積作比較。實驗數據顯示，整合超音波溫度影像及超音波彈性影像，能降低面積估測的誤差。結果說明以超音波彈性影像於聚焦式超音波熱燒灼產生的焦斑估計與量測具可行性。未來研究方向亦可應用此分析技術監控其他燒灼術之有效燒灼區域。 The purpose of this study is to integrate of ultrasonic temperature-change and elasticity-change to monitor high-intensity focused ultrasound thermal ablation process. A 2-MHz focused ultrasound transducer was employed to produce the thermal lesion ex-vivo. An ultrasound imaging system was employed to acquire RF data for post-processing based on a cross-correlation analysis technique. Estimated thermal lesion size was then quantified and then compared histologically. Preliminary results demonstrate that temperature estimation can be beneficial in the monitoring of the entire heating process and improve the specificity of thermal lesion detection. Moreover, the integration of lesion size determination can improve the thermal lesion size determination electrographic information.

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