含梳狀共聚物微胞的醫藥組合物、以及其製造方法、用途PHARMACEUTICAL COMPOSITION WITH A COMB POLYMERIC MICELLE, PRODUCTION METHOD AND USE OF THE COMPOSITION

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

102142108

專利證號

I 459975

專利獲證名稱

含梳狀共聚物微胞的醫藥組合物、以及其製造方法、用途PHARMACEUTICAL COMPOSITION WITH A COMB POLYMERIC MICELLE, PRODUCTION METHOD AND USE OF THE COMPOSITION

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2014/11/11

技術說明

本實驗設計一新穎的梳狀兩性共聚物poly(ethylene glycol)-b-poly(ε-caprolactone)-g-poly(methacrylic acid) (MPCL-g-pMAA)，利用原子轉移自由基聚合法(Atom transfer radical polymerization, ATRP)，控制MPCL及pMAA的莫耳比例，製備出三種不同親/疏水比例的兩性梳狀共聚物 MPCL-g-pMAA；此共聚物在水中可自組裝形成微胞，內層為疏水核心(PCL)，外層為親水端(PEG、MAA)。利用MAA上的的羧基(COOH)與抗癌藥物經化學鍵結形成polymer-metal complex，形成一藥物載體。另外，藉由COOH官能基，可以與功能性分子反應，來標靶腫瘤組織或做分子影像即時追蹤試劑，擴大載體在奈米醫學的應用功效。 In this study, we design a novel comb-shaped amphiphilic copolymer, poly(ethylene glycol)-b-poly(ε-caprolactone)-g-poly(methacrylic acid) (MPCL-g-pMAA), which was synthesized using atom transfer radical polymerization (ATRP). We control the molar ratio of pMAA and MPCL to form three copolymers with different hydrophilic/hydrophobic characteristics. The MPCL-g-pMAA can self-assemble into micelles in aqueous solution with hydrophobic PCL in the center and hydrophilic PEG and MAA on the surface. The carboxylic groups of pMAA were used to carry an anticancer agent, cisplatin, to form polymer-metal complexes for a drug delivery system. In addition, the COOH groups of pMAA can be reacted with functional dye molecules to perform diagnostics as well as with biomarkers to facilitate tumor targeting.

備註

連絡單位 (專責單位/部門名稱)

智財保護與科技管理組

連絡電話

07-3138030

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