METAL-ORGANIC FRAMEWORK POLYMER FOR SOLID-PHASE MICROEXTRACTIONMETAL-ORGANIC FRAMEWORK POLYMER FOR SOLID-PHASE MICROEXTRACTION

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/600,014

專利證號

US 9,421,517 B2

專利獲證名稱

METAL-ORGANIC FRAMEWORK POLYMER FOR SOLID-PHASE MICROEXTRACTIONMETAL-ORGANIC FRAMEWORK POLYMER FOR SOLID-PHASE MICROEXTRACTION

專利所屬機關 (申請機關)

中原大學

獲證日期

2016/08/23

技術說明

本專利用以開發新穎的非檔板式有機金屬骨架-高分子作為固相微萃取之靜相。此有機金屬骨架-高分子是藉由交聯劑:二甲基丙烯酸乙二醇酯，單體:甲基丙烯酸丁酯，含量為25%的有機金屬骨架，咪唑類之離子液體等混合物，於微波反應輔助下快速進行聚合。而利用此新穎之有機金屬骨架-高分子，於最佳萃取條件下，可在34分鐘內完成六種盤尼西林藥物之萃取 (盤尼西林G、盤尼西林V、新青黴素Ⅱ、苯唑西林、奈夫西林、達可西林)，並使用毛細管電層析-紫外光譜儀進行萃取後之檢測，其回收率介於63-96.2%，顯示本專利所開發之有機金屬骨架-高分子萃取管柱具有良好的感度、再現性與重複使用性 (至少可重複使用45次)。 This patent describes the fabrication of a novel hybrid metal–organic framework–organic polymer (MOF–polymer) for use as a stationary phase in fritless solid-phase microextraction (SPME) for validating analytical methods. The MOF–polymer was prepared by using ethylene dimethacrylate (EDMA), butyl methacrylate (BMA), and an imidazolium-based ionic liquid as porogenic solvent followed by microwave-assisted polymerization with the addition of 25% MOF. This novel hybrid MOF–polymer was used to extract penicillin (penicillin G, penicillin V, oxacillin, cloxacillin, nafcillin, dicloxa-cillin) under different conditions. Quantitative analysis of the extracted penicillin samples using the MOF–organic polymer for SPME was conducted by using capillary electrochromatography (CEC) coupled with UV analysis. The penicillin recovery was 63–96.2% with high sensitivity, reproducibility, and re-usability (at least 45 times). The extraction time with the proposed fabricated SPME was only 34 min.

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