阿茲海默症之分子指標MOLECULAR BIOMARKER FOR ALZHEIMER'S DISEASE

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

101114746

專利證號

I 521204

專利獲證名稱

阿茲海默症之分子指標MOLECULAR BIOMARKER FOR ALZHEIMER'S DISEASE

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2016/02/11

技術說明

本發明阿茲海默症之分子指標，係以源自於ADNP之胺基酸片段，作為早期診斷其為阿茲海默症高風險族群之判斷指標。本發明阿茲海默症之早期診斷方法，係包含：一採檢步驟，係採取一受試者之檢體，測量該檢體中的ADNP含量，其中，該檢體為血液或腦脊液；及一判斷步驟，一正常人的血液或腦脊液檢體之ADNP含量與該受試者檢體之ADNP含量的比值為一AD風險值，該AD風險值小於0.3者，則判斷該受試者屬於阿茲海默症患者之高風險族群。 Alzheimer’s disease (AD) is the most common cause of dementia of late life. The aim of this study was to utilize the proteomic approaches to establish serum protein patterns of AD. By using nano-high-performance liquid chromatography/electrospray ionization tandem mass spectrometry followed by peptide fragmentation pattern software to analyze proteome in human serum, the activity-dependent neuroprotector homeobox protein was found to exhibit significant differential expression compared with the control group and was confirmed by Western blotting and enzyme-linked immunosorbent assay. It may play an important role in slowing the progression of clinical symptoms of AD.

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