Use of indolyl and indolinyl hydroxamates for treating neurodegenerative disorders or cognitive decicits

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

15/038,671

專利證號

US 9,956,202 B2

專利獲證名稱

Use of indolyl and indolinyl hydroxamates for treating neurodegenerative disorders or cognitive decicits

專利所屬機關 (申請機關)

臺北醫學大學

獲證日期

2018/05/01

技術說明

透過藥物化學藥物設計原理，合成一系列新穎Indolyl and Indolinyl hydroxamates骨架化合物。結構上最大特色為在其Indole或是Indoline環上C2的取代基一定為氫，而其環上C3-C7位置以N-hydroxyacrylamides來取代，再搭配各種aroyl、benzenesulfonyl、aryl、OR…….等各種官能基而架構此一系列化合物；我們發現小分子藥物Indolyl and Indolinyl hydroxamates具有顯著神經保護之能力，可有效治療失智症及脊髓損傷。 The present disclosure is based, at least in part, unexpected discovery that the compound having formula , provides neuron protective activity to a subject such as human, wherein is a single or double bond; B is R, C(O)R, CH2R, SO2R, SO3R, or SO2NRR’; C is R, C(O)R, CH2R, SO2R, or CH=CHC(O)NHOH; each Xa, Xb, Xc and Xd are independently R, halogen, nitro, nitroso, OR, or CH=CHC(O)NHOH; and each R and R’ are independently H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl. The results of this invention suggest that these active compounds are potential lead compounds for use as therapeutic agents for the treatment of neuronal injury, such as dementia or spinal cord injury.

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