情緒性腦電波造影方法Methodological applications of emotional voices for emotional mismatch negativity

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

101129761

專利證號

I 482611

專利獲證名稱

情緒性腦電波造影方法Methodological applications of emotional voices for emotional mismatch negativity

專利所屬機關 (申請機關)

國立陽明大學

獲證日期

2015/05/01

技術說明

儘管已有證據顯示在年齡非常小的孩童身上，大腦就已經發展出特別針對人類語音進行處理的神經系統，然而，至今尚未證實，如此對同物種語音處理的神經系統是否存在於新生兒的大腦中，本研發實驗採用情緒語音搭配非配對實驗典範，用以量測事件相關非配對腦電波，以帶有不同情緒之人類語音『答答』，佐以控制語音基本聲學特徵之合成複雜聲與簡單聲，對足月1至5歲新生兒進行神經功能掃描。實驗一：快樂的情緒語音能夠激發大腦右側化的神經反應，而相較於控制組非語音聲刺激則無此現象。實驗二：相較於中性與快樂的情緒語音，害怕的情緒語音能夠激發較強的神經活動，而此現象並不存在性別差異。實驗三：大腦神經活動能夠區分生氣與快樂的情緒語音，然而使用控制組非語音聲刺激卻無法看到相同的結果。實驗結果顯示，區分情緒語音與區分低階聲普刺激所引發的大腦活動並不相同，新生兒的大腦在生命非常早期即針對人類語音特化出情緒處理的神經系統，並非透過一般聲音處理系統處理。 Although the voice-sensitive neural system emerges very early in development, it has yet to be demonstrated whether the neonatal brain is sensitive to voice perception. We measured the EEG mismatch response (MMR) elicited by emotionally spoken syllables “ dada ” along with correspondingly synthesized nonvocal sounds, whose fundamental frequency contours were matched, in 98 full-term newborns. In Experiment 1, happy syllables relative to nonvocal sounds elicited an MMR lateralized to the right hemisphere. In Experiment 2, fearful syllables elicited stronger amplitudes than happy or neutral syllables. In Experiment 3, angry versus happy syllables elicited an MMR, although their corresponding nonvocal sounds did not. Here, we show that affective discrimination is selectively driven by voice processing per se rather than low-level acoustical features and that the cerebral specialization for human voice and emotion processing emerges over the right hemisphere during the first days of life.

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