SEROLOGICAL MARKERS FOR DETECTING COLORECTAL CANCER AND THEIR APPLICATION FOR INHIBITING COLORECTAL CANCER CELLS

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

13/892,011

專利證號

US 9,835,636 B2

專利獲證名稱

SEROLOGICAL MARKERS FOR DETECTING COLORECTAL CANCER AND THEIR APPLICATION FOR INHIBITING COLORECTAL CANCER CELLS

專利所屬機關 (申請機關)

長庚大學

獲證日期

2017/12/05

技術說明

大腸直腸癌為發生率極高的癌症之一且對於公眾健康造成極大的負擔。因此，如何對大腸直腸癌早期偵測與治療，以達到減少大腸直腸癌所造成的死亡率，一直是該領域的一大課題。本發明係有關stomatin-like protein 2 (SLP-2), phospholipid scramblase 1 (PLSCR 1) 與 transport protein Sec61 subunit beta (SEC61β)蛋白於大腸直腸癌形成中扮演的角色，並且發明特色為提供一種用於篩檢、預後評估、治療成效評估或治療大腸直腸癌之方法，係藉由偵測SLP-2, PLSCR 1 及/或SEC61β蛋白，與投予抗體或短具干擾性RNA針對對抗SLP-2, PLSCR 1 , SEC61β蛋白中1種以上，或投予一包含此種抗體或短具干擾性RNA 之組合物。本發明提供一種用於診斷大腸直腸癌或評量/決定一患有大腸直腸癌之患者預後的方法，係使用擇自於SLP-2, PLSCR 1 , SEC61β 之過度表現蛋白1種以上。為實現此一目標，SLP-2, PLSCR 1 , SEC61β 可作為一新穎的針對大腸直腸癌的血清學生物標記。又，所揭示者為鑑別用以治療及預防大腸直腸癌的化合物的方法，利用觀察大腸直腸癌中SLP-2, PLSCR 1 , 及/或SEC61β中1種以上過度表現作為指標、或觀察SLP-2, PLSCR 1及/或SEC61β中1種以上之所影響的細胞增殖作用作為指標。尤其，SLP-2可作為一預後的生物標記，有用於臨床設定；再者，標靶PLSCR1 之活性或利用PLSCR1抗體，可呈現一有前景的療法以發展新類型的抗癌藥物。 The present invention relates to the roles of stomatin-like protein 2 (SLP-2), phospholipid scramblase 1 (PLSCR 1) and transport protein Sec61 subunit beta (SEC61β) in colorectal cancer carcinogenesis and features a method for screening, prognosis, monitoring therapy by detecting the SLP-2, PLSCR 1 and/or SEC61β , or for treating or preventing colorectal cancer. The present invention features methods for diagnosing colorectal cancer or assessing/determining the prognosis of a patient with colorectal cancer, using one or more biomarkers selected among SLP-2, PLSCR 1 and/or SEC61β. Also, disclosed are methods of identifying compounds for treating and preventing colorectal cancer, using an index on the over-expression of one or more of SLP-2, PLSCR 1 and/or SEC61β in the colorectal cancer. SLP-2 serve as a prognostic biomarker in a clinical setting; furthermore, targeting the activity of PLSCR1 present a promising therapeutic approach to develop new types of anti-cancer drugs.

備註

中文名稱:大腸直腸癌檢測標誌及其應用

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