MICROFLUIDIC DEVICE AND METHOD OF MAKING THE SAME

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

15/795,639

專利證號

US 10,661,277 B2

專利獲證名稱

MICROFLUIDIC DEVICE AND METHOD OF MAKING THE SAME

專利所屬機關 (申請機關)

國立臺灣師範大學

獲證日期

2020/05/26

技術說明

本專利主要揭露一種利用雷射(Laser)微流體元件結構(Microfluidic device structures)製程於細胞檢測晶片技術。不同於傳統光學微影 (Photolithography)、機械CNC車削及長脈衝雷射(Long-pulse laser)之製程，本發明研究會利用超快雷射(Ultrafast laser)之超短(Ultra-short)脈衝(10-12~10-15 sec)製程與奈米線(Nanowires)製程，並以電性檢測(Electrical detection)的概念，設計與製作微型實驗室晶片(Lab-on-a-chip)，即成型之多尺度結構之微流體元件(Multiscale-structure microfluidic devices)進行腫瘤細胞的偵測。本案是採以細胞捕捉的機制，設計微流體元件之幾何結構，以能使具有微量補捉腫瘤細胞的能力，達到同時有補捉(Trapping)與偵測(Detection)之功能，建立微流體製程技術於腫瘤細胞檢測，有助於在腫瘤細胞病變上能提早預防及治療控制。 According to one aspect of the disclosure, the microfluidic device includes a substrate, a microchannel, a plurality of spaced-apart pillars, and a porous nanofiber web structure.The spaced-apart pillars are disposed in the microchannel. Each of the pillars has a pillar top surface that is lower in level than the substrate top surface. The porous nanofiber web structure is formed in the microchannel and includes a first web portion residing in a space formed among the pillars. According to another aspect of the disclosure, a method of making a microfluidic device includes: ablating a substrate to form a microchannel and a plurality of spaced-apart pillars disposed in the microchannel by using an ultrafast laser; and electrospinning a polymer solution to form in the microchannel a porous nanofiber web structure that covers top surfaces of the spaced-apart pillars and extends in a space formed among said pillars.

備註

連絡單位 (專責單位/部門名稱)

產學合作組

連絡電話

77341329

網址