高分子材料包覆蜂膠類黃酮微米粉體之方法

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

102145952

專利證號

I 486179

專利獲證名稱

高分子材料包覆蜂膠類黃酮微米粉體之方法

專利所屬機關 (申請機關)

國立中興大學

獲證日期

2015/06/01

技術說明

一種高分子材料包覆蜂膠類黃酮微米粉體之方法，以索氏萃取法從蜂膠粉體中提取類黃酮粉粒體，再以超臨界流體抗溶沈澱法將高分子材料包覆類黃酮粉粒體表面，成為高分子/類黃酮共沈澱物。通過索氏萃取法萃取蜂膠粉體，可獲得最大的類黃酮萃取量。以高分子/類黃酮進料溶液經由超界流體抗溶沈澱法，將高分子材料包覆於類黃酮粉粒體表面，阻隔其氣味，並使被包覆物與外界環境隔絕，安定、避免氧化、控制釋放、易儲存及方便包裝的特性；製得高分子/類黃酮複合共沈澱物，類黃酮載藥量為50%，且溶解速度較未包覆高分子之類黃酮粉粒體提昇3倍。 In this study, pressurized carbon dioxide anti-solvent (PAS) co-precipitation method was applied for encapsulation of propolis by using water soluble poly ethylene glycol (PEG). Initially, 78% of flavonoids were recovered in the ethanol extracts from the Brazilian propolis. Several preliminary experiments of the PAS co-precipitations were carried out in searching for major process conditions influencing the drug content of propolis in PEG. The micro-sized amorphous particulates of the propolis encapsulated on the surface of PEG were evidenced by the x-ray diffraction patterns. It was also presented that the 50% of drug content and total weight 17.7 mg of the flavonoids were successfully encapsulated by 25.5 mg of PEG in PAS. The maximal total yield of the PAS precipitation attained 64% and the recovery of total recovery of flavonoids achieved 60%.

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