聚乙二醇-聚己內酯接枝聚丙烯酸高分子之合成及應用Preparation of Poly(ethylene glycol)-b-poly(ε-caprolactone)-poly(acrylic acid) and its application

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

101145928

專利證號

I 462746

專利獲證名稱

聚乙二醇-聚己內酯接枝聚丙烯酸高分子之合成及應用Preparation of Poly(ethylene glycol)-b-poly(ε-caprolactone)-poly(acrylic acid) and its application

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2014/12/01

技術說明

以開環反應合成前驅高分子poly(ethylene glycol)-b-poly(ε-caprolactone) (PEC)，之後，利用PEC末端之OH基與Poly(acrylic acid)上之COOH官能機於DMSO中進行接枝反應，以形成Poly(ethylene glycol)-b-poly(ε-caprolactone)-grafted poly(acrylic acid) (PAA-PEC) 之雙性接枝高分子。於其應用上以共沉澱之方式將接枝高分子Poly(ethylene glycol)-b-poly(ε-caprolactone)-grafted poly(acrylic acid) (PAA-PEC)包覆於磁性奈米四氧化三鐵顆粒上，可以獲得兼具有高藥物包覆率、高生物相容性、高藥物毒殺能力、高磁共振成像能力之磁性奈米顆粒。 Poly(ethylene glycol)-b-poly(ε-caprolactone)-grafted poly(acrylic acid) (PAA-PEC) was synthesized to chemically or physically coated onto magnetic Fe3O4. The chemically PAA-PEC-coated iron oxide (PAA-PEC-IO) nanoparticles were prepared by a simple coprecipitation method. On contrast, oleic acid-coated Fe3O4 was physically encapsulated into the PAA-PEC core via an emulsion technique (PAA-PEC-OA-IO). The similar iron content was controlled in the both PAA-PEC-IO and PAA-PEC-OA-IO systems. The particle diameters, morphologies, superparamagnetism, and transversal relaxivity (r2) were studied and compared in both the systems. The PAA-PEC-IO (109.46 mM-1 s-1) had a larger r2 value than the PAA-PEC-OA-IO (33.52 mM-1 s-1). The higher drug loading efficiencies were found in the PAA-PEC-IO (9.78% for Nile red and 5.96% for DOX) than in the PAA-PEC-OA-IO (1.58% for Nile red and 1.94% for DOX).

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