PREPARATION OF PH-RESPONSIVE NANOPARTICLES AND PROMOTED DELIVERY OF ANTICANCER DRUGS INTO DEEP TUMOR TISSUES AND APPLICATION THEREOF

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

14/931,872

專利證號

US 9,980,919

專利獲證名稱

PREPARATION OF PH-RESPONSIVE NANOPARTICLES AND PROMOTED DELIVERY OF ANTICANCER DRUGS INTO DEEP TUMOR TISSUES AND APPLICATION THEREOF

專利所屬機關 (申請機關)

國立清華大學

獲證日期

2018/05/29

技術說明

本發明是關於一種酸鹼應答型奈米微粒，由酸鹼應答型高分子材料以及聚乳酸烴基乙酸共聚物（PLGA）於水相中，透過疏水性作用力互相聚集而形成，其中該雙性高分子包含聚乙二醇（PEG）衍生物以及組胺酸（Histidine）衍生物。該酸鹼應答型奈米微粒之疏水核心區可包載化療藥物、光熱藥劑、顯影劑、奈米金屬粒子或其組合，而透過該酸鹼應答型奈米微粒本身特殊的表面電荷轉換功能，使其能在腫瘤組織微酸環境中大量累積並有效被癌細胞胞飲與滲透至腫瘤深層區域，進而顯著抑制腫瘤生長。 The present invention discloses a preparation method of pH-responsive nanoparticles composed of pH-sensitive amphiphilic material and poly lactic-co-glycolic acid (PLGA). The amphiphilic materials consist of polyethylene glycol (PEG) derivatives and Histidine derivatives. By the coating of the pH-sensitive amphiphilic materials on the surface of PLGA-based hydrophobic core loaded with anti-cancer drugs or contrast agents or photothermal agents or metallic nanoparticles or a combination thereof, the cellular uptake and tumor penetration of the pH-responsive nanoparticles were significantly enhanced by their unique surface charge conversion in weak acidic tumor environment, thus efficiently killing tumor cells.

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智財技轉組

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03-5715131-62219

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