用於評估化療效果與早期偵測的雙波段熱圖譜分離演算法DUAL-SPECTRUM HEAT PATTERN SEPARATION ALGORITHM FOR ASSESSING CHEMOTHERAPY TREATMENT RESPONSE AND EARLY DETECTION

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

13/657,796

專利證號

US 8,582,852 B2

專利獲證名稱

用於評估化療效果與早期偵測的雙波段熱圖譜分離演算法DUAL-SPECTRUM HEAT PATTERN SEPARATION ALGORITHM FOR ASSESSING CHEMOTHERAPY TREATMENT RESPONSE AND EARLY DETECTION

專利所屬機關 (申請機關)

國立臺灣大學

獲證日期

2013/11/12

技術說明

在紅外線影像中每一個像素點均含有正常與不正常組織所釋放出來的紅外線訊息。因此，研究建構一套雙波段熱圖譜分離演算法來量化出影像上高溫組織區域(qH)，在中波（MIR）與長波（LIR）紅外線影像中推估出高溫組織區與基礎體溫組織區的含量。經由多時間點對位，定量分析這些高溫組織隨著化療時間而變化的現象，推估潛藏於高溫組織下可能的癌組織含量變化。初步結果顯示在經過化療後，qH map之高溫組織平均能量的變化都有逐漸變小的趨勢，可藉此結果來有效的追蹤並且評估乳癌病患的化療成效。 Infra-red images of tumors carry the information of normal and cancerous tissues in every pixel. We developed a Dual-Spectrum Heat Pattern Separation (DS-HPS) algorithm to quantify the energy from the area of the high temperature tissues, called qH map, and decompose the body surface into the high and normal temperature areas based on a pair of middle-wave Infra-red images and long-wave Infra-red images. Further, with longitudinal registration, we can detect the cancerous tissues and assess the chemotherapy treatment response on a pixel by pixel basis according to the change of the qH map derived by the DS-HPS algorithm. The preliminary result shows the area and the qH values in the high temperature area are decreased as the patients receive more chemotherapy. These suggest the proposed algorithm could capture the incremental or decremental of the energies emitted by the cancerous tissues, which has the potentials for chemotherapy assessment and early detection.

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